15155 - ISTH "High Throughput Platelet Assays"

Through its educational arm, the ISTH Academy, the International Society on Thrombosis and Haemostasis (ISTH) has begun hosting a series of webinars on practical thrombosis and haemostasis issues that scientists and physicians frequently confront. These webinars will allot time for participants to ask questions and will cover the latest information on relevant topics.


Part ITim Warner:  Born aggregometry to high throughput 96 well plates; which test should we use?  
Presentation will briefly cover the principles and history of light transmission aggregometry leading to current user guidelines and recommendations supported by consensus agreements.  The fundamentals of 96-well plate aggregometry will be introduced and compared to those of light transmission aggregometry.  The pros and cons of using LTA and 96-well plate aggregometry in clinical and research settings will be discussed.


Part II:  Johan Heemskerk: Monitoring platelet aggregation under flow: from commercial to custom built assays
The aim of this presentation is to provide a general background of the past and present use of flow chamber devices to measure platelet aggregation and thrombus formation in whole blood. Characteristics for flow chamber tests are: that platelet adhesion and aggregation can be monitored in real time at well defined venous or arterial wall shear rates; that assays can be performed in a point-of-care setting using only small volumes of whole blood with limited handling; and that coagulation can be introduced as wished by the experimentator. Discussed will be the various types of devices and the ways of application for both experimental research questions and (pre)clinical testing of blood samples. Recent developments are widely diverging: from specialized devices where platelet aggregation is assessed in the presence of endothelial or progenitor cells; microfluidic devices that can be prepared in your own lab; to devices with microspot coatings giving a multiparameter insight into the process of thrombus formation for a certain patient.
Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
Designation of Credit Statement:
The Medical College of Wisconsin designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Please note: The course fee is $25.00 in addition to a $2.50 processing fee which is assessed for all electronic registrations.

Target Audience

  • Clinicians
  • Researchers
  • Nurses

Learning Objectives

  • To improve pathophysiological knowledge on occurrence of unwarranted clot formation 
  • To improve clinical knowledge on state-of-the-art prevention and management of venous thrombosis
Additional information


Cary Clark
Phone Number: 
+1 (919) 929-3807
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.
Course opens: 
Course expires: 
Planning Committee:
Yukio Ozaki
Geoff Barnes
Chris Ward
Mark Crowther
Marcel Levi
Cary Clark
Stephen Watson
Suzanne Cannegieter
Willem Lijfering


  • Tim Warner, PhD, Barts & the London School of Medicine & Dentistry, United Kingdom
  • Johan Heemskerk , PhD, University of Maastricht, The Netherlands
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:


Commercial Interest


Yukio Ozaki


Advisory Board

Tim Warner, PhD



In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships. These relationships were reviewed via the MCW conflict of interest resolution process and resolved


Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.


Please login or register to take this course.

Required Hardware/software

To view the webcast on your computer go to https://www.isth.org/  click the Events/Webinars tab and view the ISTH 2015 Archived Webinars

Participant Privacy