15162 - ISTH "Thromboembolism in Cancer Patients"

Biological Mechanisms Involved in Cancer Coagulopathy – Janusz Rak
The presentation will review some of the biological mechanisms linking thrombosis to cancer progression, including the role of tumour-associated vascular anomalies, systemic nature of the advanced disease and the impact of oncogenic mutations on the coagulant phenotype of cancer cells. Experimental evidence will also be considered in relation to the possible involvement of the coagulation system effectors, especially tissue factor, in the biology cancer cells, including events surrounding tumour initiation, angiogenic switch, inflammatory responses and their therapeutic implications.

Prevention and Treatment – Alok Khorana
Overview of approaches to prevention including identifying patients at high risk for venous thromboembolism. The talk will also cover and best practices in treatment of cancer-associated thrombosis


Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
Designation of Credit Statement:
The Medical College of Wisconsin designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Please note: The course fee is $25.00 in addition to a $2.50 processing fee which is assessed for all electronic registrations.
More information and online registration:  http://www.prolibraries.com/isth/


Target Audience

Clinicians and trainees who are interested in the biological mechanisms linking cancer and thrombosis and how to prevent and treat thrombosis in cancer patients.  Researchers and non-medical trainees with an interest in the vascular abnormalities in cancer would also be interested in the presentation.


Learning Objectives

At the conclusion of this activity, I will be able to:

  • To consider the convergence of vascular, blood-related and tumour-related events underlying thrombosis in cancer patients.
  • To appreciate the complexity and disease-specific aspects amongst processes occurring at the tumour-vascular interface which contribute to coagulation system activation in cancer.
  • To discuss the possible impact of coagulation system activation on the biology of cancer cells.
  • To understand the link between oncogenic driver events and their related changes in the molecular repertoire of coagulant effector genes (coagulome) in specific cancer subtypes.
  • To highlight coagulopathy as a systemic manifestation of the malignant process and a step in the continuum of coordinated biological responses, including inflammation, angiogenesis and tissue repair programs.
  • Understand risk assessment for cancer-associated thrombosis
  • Identify appropriate strategies for thromboprophylaxis
  • Outline best treatments of cancer-associated thrombosis
Additional information


Cary Clark
Phone Number: 
+1 (919) 929-3807
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.
Course opens: 
Course expires: 
Planning Committee:
Yukio Ozaki
Geoff Barnes
Chris Ward
Cary Clark
Stephen Watson
  Alok A. Khorana, MD
 Janusz Rak, MD, PhD
 Moderator, Chris Ward
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:  




Chris Ward, MD


Advisory Board, Speaker


Pfizer, BMS

Advisory Board, Speaker



Advisory Board, Speaker



Advisory Board



Steering Committee Member, Speaker

Geoff Barnes

BMS, Pfizer, Blue Cross Blue Shield of Michigan

Primary Investigator & Co-Investigator

Yukio Ozaki


Advisory Board

Janusz RakNX PharmaGenIntellectual Property
Alok KhoranaLeoSteering Committee
 JanssenSteering Committee

In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships. These relationships were reviewed via the MCW conflict of interest resolution process and resolved



Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.


Please login or register to take this course.

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