15265 - ISTH "Tissue Factor and Cancer"


Dr. Ruf’s presentation will cover mechanisms supported by the tissue factor (TF) pathway in primary tumor growth and metastasis. Interventional strategies to block TF’s procoagulant and signaling activities in malignancy will be discussed.

Tissue factor-positive microparticles in cancer-associated thrombosis – Nigel Mackman

Dr. Mackman’s presentation will describe the measurement of tissue factor (TF)-positive microparticles (MPs) in plasma samples from cancer patients. It will also summarize studies that show a relationship between elevated levels of MP-TF activity and VTE in pancreatic cancer patients but not other types of cancer patients. Other mechanisms of cancer-associated thrombosis will be discussed. 


Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
Designation of Credit Statement:
The Medical College of Wisconsin designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Please note: The course fee is $25.00 in addition to a $2.50 processing fee which is assessed for all electronic registrations.
More information and online registration:  http://www.prolibraries.com/isth/


Target Audience

Physician scientists and translational research in thrombosis and hemostasis research and oncology

Learning Objectives

At the conclusion of this activity, I will be able to:

  • Understand the contributions of TF initiated coagulation and cell signaling to tumor progression
  • Obtain an overview of preclinical efficacy of inhibitors targeting TF in animal models of metastasis and tumor growth
  • Acquire insights into open questions and directions of translational research in the field of cancer and thrombosis
  • Provide information on the strengths and weaknesses of the different methods to measure levels of TF+ MPs in plasma samples from patients.
  • The potential utility of MP-TF activity as a biomarker of thrombotic risk in patients will be discussed.
Additional information


Cary Clark
Phone Number: 
+1 (919) 929-3807
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.
Course opens: 
Course expires: 
Planning Committee:
Yukio Ozaki
Geoff Barnes
Chris Ward
Cary Clark
Stephen Watson
Wolfram Ruf - "Tissue Factor in Tumor Growth and Metastasis"
Nigel Mackman - "Tissue Factor-Positive Microparticles in Cancer-Associated Thrombosis"
Ketan Kulkarni
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:  




Chris Ward, MD


Advisory Board, Speaker


Pfizer, BMS

Advisory Board, Speaker



Advisory Board, Speaker



Advisory Board



Steering Committee Member, Speaker

Geoff Barnes

BMS, Pfizer, Blue Cross Blue Shield of Michigan

Primary Investigator & Co-Investigator

Yukio Ozaki


Advisory Board

Wolfram RufIconic TherapeuticsConsultant

In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships. These relationships were reviewed via the MCW conflict of interest resolution process and resolved



Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.


Please login or register to take this course.

Required Hardware/software

To view the webcast on your computer go to https://www.isth.org/  click the Events/Webinars tab and view the ISTH 2015 Archived Webinars