Hematopoietic cell transplantation (HCT) is the only known curative therapy for many patients with hematologic malignancies and other blood, immune system, and metabolic disorders. In the United States each year, more than 20,000 HCTs are performed. As a result of advances in supportive care and transplantation techniques, this number is expected to increase significantly. HCT patients are on highly complex medication regimens and many of them are receiving long‐term follow up in the community. Practitioners working with HCT patients must be skilled in the management of transplant medication drug‐drug and drug‐food interactions, therapeutic drug monitoring, recognition and management of adverse effects, provision of supportive care, and selection of appropriate medications.