Von Willebrand Disease (VWD): New Insights - October 15, 2014 (14:00-15:00 GMT)

Carrboro, NC US
October 15, 2014

There is a lack of knowledge on how to diagnose, treat and manage patients with von Willebrand disease.

This presentation will focus on the advances made in understanding the molecular pathogenesis of von Willebrand disease (VWD) in the past two decades. The presentation will begin with a brief update on the fundamental knowledge of von Willebrand factor structure and function. This introduction will then be followed by a consideration of the molecular genetic pathology responsible for each of the subtypes of VWD. The presentation will highlight the strengths and weaknesses of current molecular genetic knowledge for VWD as it pertains to the potential for using this information in genetic diagnosis of this disorder.  The presentation will end with a brief discussion of future lines of investigation required to further enhance our pathogenetic understanding of this multifaceted, complex genetic trait.      

The presentation will then address the diagnosis and management of von Willebrand disease (VWD). After a brief discussion of the classification of VWD the presentation will focus on the bleeding history, including the value of bleeding assessment tools and bleeding scores, the laboratory tests required for diagnosis as well as subtyping, and the potential new roles for ratios of von Willebrand factor (VWF) parameters and the VWF propeptide assay in the diagnostic work-up of VWD. In the second part of the presentation a practical approach to the treatment of VWD will be presented. 


Accreditation Statement:
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
Designation of Credit Statement:
The Medical College of Wisconsin designates this Live Activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Hours of Participation for Allied Health Professionals:
The Medical College of Wisconsin designates this activity for up to 1.0 hours of participation for continuing education for allied health professionals.  

Target Audience

  • Clinicians
  •  Researchers
  • Nurses

Learning Objectives

  • Review and discuss the Von Willebrand Disease structure and function
  • Examine the genetic knowledge of Von Willebrand Disease
  • Discuss the diagnosis and management of VWD
Additional information


Cary Clark
Phone Number: 
+1 (919) 929-3807
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.
Course opens: 
Course expires: 
Event starts: 
10/15/2014 - 9:00am
Event ends: 
10/15/2014 - 10:00am
ISTH Webinar Library
Visit: http://www.prolibraries.com/isth/
Once a Month
Carrboro, NC 27510
United States
Yukio Ozaki,
Stephen Watson,
Geoffrey Barnes, MD
Chris Ward,
Cary Clark


David Lillicrap, MD FRCPC
Queen’s University, Kingston, Canada
Jeroen Eikenboom, MD, PhD
Leiden University Medical Center, The Netherlands

All persons in control of content have NO relevant financial relationships to disclose with the exception of the following person(s):

Geoffrey Barnes, MDBristol-Myers SquibbPrimary Investigator
 PfizerPrimary Investigator
 Blue Cross Blue Shield of MichiganCo-Investigator


Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.


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