Program Description: 

ISTH Academy Webinar: New Roles for Platelet Secretion in Hemostasis


“Platelet Polyphosphates in Hemostasis”
Jim Morrissey
In 2004, polyphosphate, which consists of linear chains of inorganic phosphate, was found to be abundant in the dense granules of human platelets and to be secreted upon platelet activation. This webinar will discuss recent research findings revealing that polyphosphate is a potent modulator of the blood clotting system, functioning at the nexus of hemostasis and inflammation.
Dr. Morrissey is the Roy & Eva Hong Professor of Molecular & Cellular Biology in the Biochemistry Department at the University of Illinois at Urbana-Champaign. He received his Ph.D. from the University of California at San Diego and did postdoctoral research at the University of Oxford and the Scripps Research Foundation. Starting with cloning of tissue factor in 1987, his research has centered on regulation of the blood clotting system in normal hemostasis and thrombotic diseases. In 2006, his laboratory discovered that inorganic polyphosphate, which is released from activated human platelets, is a potent modulator of the blood clotting system with important roles in hemostasis, thrombosis and inflammation. Dr. Morrissey serves on the ISTH Council and is an associate editor of the Journal of Thrombosis and Haemostasis.
“Platelet alpha-granules in hemostasis”
Walter Kahr
Activated platelets can secrete a variety of different proteins carried in alpha-granules that can influence a broad range of physiological processes. This webinar will discuss the development of platelet alpha-granules and examine how granule-borne proteins contribute to hemostasis. 

Dr. Kahr is Associate Professor of Paediatrics and Biochemistry at the University of Toronto and a Senior Scientist in the Cell Biology Program at the Research Institute of the Hospital for Sick Children (SickKids), where he is also a staff physician in the Division of Haematology/Oncology managing patients with bleeding/clotting problems. He received his MD and PhD from the University of Toronto and did post-doctoral research in the Department of Pathology and Molecular Medicine at McMaster University in Hamilton. Beginning with the discovery that patients with Québec platelet disorder have abnormal expression of urokinase in their platelets, Dr. Kahr’s research has focused on studies of inherited platelet defects and the development of platelet alpha-granules. His group played a key role in the discoveries that VPS33B, its binding partner VPS16B, and NBEAL2 are required for alpha-granule formation by investigating patients with mutations causative for ARC syndrome (VPS33B and VPS16B) and gray platelet syndrome (NBEAL2). He is currently investigating the roles of these and other proteins in platelet development and function.


Stephanie Smith

Dr Smith is a Research Assistant Professor in the Department of Biochemistry at the University of Illinois. Her work focuses on the roles of polyphosphate in hemostasis, thrombosis, and inflammation.


Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
Designation of Credit Statement:
The Medical College of Wisconsin designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
More information and online registration: 


Target audience: 

Basic and clinical scientists, including platelet biologists, vascular biologists and hematologists, interested in translational research


Learning objectives: 

At the end of this Webinar, the participants will be able to:

  • Explain the role of polyphosphate in modulating blood clotting
  • Distinguish between the procoagulant and proinflammatory actions of polyphosphate
  • Explore the possibility of polyphosphate as a novel prohemostatic agent, and also as a possible antithrombotic drug target
Faculty & credentials: 
Planning Committee:
Geoffrey Barnes, MD
Chris Ward, PhD
Stephen Watson, PhD
Yukio Ozaki

Part I: Platelet Polyphosphates in Hemostasis
James Morrissey, University of Illinois (USA)

Part II: Platelet Alpha-Granules in Hemostasis
Walter Kahr, University of Toronto (Canada)

Moderator: Stephanie Smith, University of Illinois (USA)


All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:  





Geoffrey Barnes, MDPortolaConsulting
 Blue Cross Blue Shield of MichiganResearch
Chris Ward, PhDBayerSpeaker
 Boehringer-IngelheimSpeaker, Advisory Board
 BMS/PfizerSpeaker, Advisory Board
Yukio OzakiThe Sysmex CorporationAdvisory Board
James MorrisseyrEVO Biologics, Alnylam Pharmaceuticals, Novo Nordisk, Smartzyme, Diagnostica Stago, Prev Thro, Inc.Consultant, Inventor, Co-owner

In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships. These relationships were reviewed via the MCW conflict of interest resolution process and resolved






Lacey Schmeidler, MA
Phone number: 
+1 (919) 929-3807
Session date: 
10/28/2016 - 9:00am to 10:00am CDT
ISTH Webinar Library Once a Month
Carrboro, NC 27510
United States
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.

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