- 1.00 AMA PRA Category 1 Credit(s)™AMA PRA Category 1 Credit(s)™
- 1.00 Hours of ParticipationHours of Participation credit.
Dr. Kahr is Associate Professor of Paediatrics and Biochemistry at the University of Toronto and a Senior Scientist in the Cell Biology Program at the Research Institute of the Hospital for Sick Children (SickKids), where he is also a staff physician in the Division of Haematology/Oncology managing patients with bleeding/clotting problems. He received his MD and PhD from the University of Toronto and did post-doctoral research in the Department of Pathology and Molecular Medicine at McMaster University in Hamilton. Beginning with the discovery that patients with Québec platelet disorder have abnormal expression of urokinase in their platelets, Dr. Kahr’s research has focused on studies of inherited platelet defects and the development of platelet alpha-granules. His group played a key role in the discoveries that VPS33B, its binding partner VPS16B, and NBEAL2 are required for alpha-granule formation by investigating patients with mutations causative for ARC syndrome (VPS33B and VPS16B) and gray platelet syndrome (NBEAL2). He is currently investigating the roles of these and other proteins in platelet development and function.
Dr Smith is a Research Assistant Professor in the Department of Biochemistry at the University of Illinois. Her work focuses on the roles of polyphosphate in hemostasis, thrombosis, and inflammation.
Basic and clinical scientists, including platelet biologists, vascular biologists and hematologists, interested in translational research
At the end of this Webinar, the participants will be able to:
- Explain the role of polyphosphate in modulating blood clotting
- Distinguish between the procoagulant and proinflammatory actions of polyphosphate
- Explore the possibility of polyphosphate as a novel prohemostatic agent, and also as a possible antithrombotic drug target
Part I: Platelet Polyphosphates in Hemostasis
James Morrissey, University of Illinois (USA)
Part II: Platelet Alpha-Granules in Hemostasis
Walter Kahr, University of Toronto (Canada)
Moderator: Stephanie Smith, University of Illinois (USA)
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:
|Geoffrey Barnes, MD||Portola||Consulting|
|Blue Cross Blue Shield of Michigan||Research|
|Chris Ward, PhD||Bayer||Speaker|
|Boehringer-Ingelheim||Speaker, Advisory Board|
|BMS/Pfizer||Speaker, Advisory Board|
|Yukio Ozaki||The Sysmex Corporation||Advisory Board|
|James Morrissey||rEVO Biologics, Alnylam Pharmaceuticals, Novo Nordisk, Smartzyme, Diagnostica Stago, Prev Thro, Inc.||Consultant, Inventor, Co-owner|