
Douglas Vaughan "Plasminogen activation and disease"
Dr. Vaughan will discuss how alterations in the fibrinolytic system contribute to thrombotic and non-thrombotic human disease. He will also review the effects of the fibrinolytic system on aging.
Robert Medcalf "Novel regulators of fibrinolysis"
Professor Medcalf will discuss the various means by which the fibrinolytic (plasminogen activating) system is activated and will also highlight the broadening role of this system in biology, particularly in relation to its effects on the immune response and in the central nervous system.
Moderator: Paul Kim
At the end of this Webinar, the participants will be able to:
- Review plasminogen activator system.
- Discuss role of plasminogen activators and PAI – 1 in regulating metabolism of peptide hormones
- Review human diseases that might be treated by inhibiting PAI-1
- To appreciate the broader role of the fibrinolytic system.
Douglas Vaughan, MD, is Irving S. Cutter Professor and Chairman of the Department of Medicine at the Northwestern University Feinberg School of Medicine in Chicago, IL. He received his MD degree from the University of Texas Southwestern Medical School in Dallas and completed his internship and residency in Internal Medicine at Parkland Memorial Hospital/Veterans Administration Medical Center, also in Dallas. He completed his fellowship in Cardiology at Brigham and Women's Hospital and Harvard Medical School in Boston, MA. He is a fellow of the American College of Cardiology, and has been elected to membership in the American Society for Clinical Investigation and the Association of American Physicians.
Prof Robert Medcalf is a NHMRC Principal Research Fellow working at the Australian Centre for Blood Diseases at Monash University. His major research focus has been on the role of the fibrinolytic system not only in its capacity to remove blood clots, but also its broader effects in removing misfolded proteins, the immune response and its other roles in the brain. For the latter, he has had a strong interest on how tissue type plasminogen activator (t-PA) modulates blood brain barrier permeability and the relationship of this in traumatic brain injury and in the use of thrombolytic agents in ischemic stroke.
Prof Medcalf was the recipient of the 2016 ISFP Prize and was also Associate Editor of J Thromb Haemost from 2008-2014 and will be Congress President of the ISTH congress being held in Melbourne in 2019.
Paul Kim is an Assistant Professor at McMaster University and Thrombosis and Atherosclerosis Research Institute located in Hamilton, Canada. Dr. Kim’s research focuses on characterizing the biochemical properties of coagulation and fibrinolytic protein factors, including the mechanism(s) of prothrombin activation by the prothrombinase complex, mechanism(s) of plasminogen activation, and mechanism(s) of thrombin-activable fibrinolysis inhibitor (TAFI) activation by the thrombin-thrombomodulin complex. Dr. Kim has served as the co-chairman of the International Society on Thrombosis and Haemostasis (ISTH) Scientific and Standardization Committee (SSC) on fibrinolysis since 2012 and is the next chairman of the committee. He is also the ex-officio council member of the International Society for Fibrinolysis and Proteolysis (ISFP) and has served as an international advisory board member of the ISFP. Dr. Kim is also an Editorial Board member of the Journal of Thrombosis and Haemostasis.
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:
Name | Company | Role |
| Geoffrey Barnes, MD | BMS/Pfizer, Blue Cross Blue Shield of MI, Aralez | Research Grant, Consulting |
| Chris Ward, PhD | Alexian, Bayer, Boehringer Ingelheim, Roche, Pfizer/BMS, Sanofi-aventis, CSL, Janssen, Amgen | Speaker, Advisory Board, Sponsored attendee, Speaker, Project Supervisor |
Contact
- 1.00 AMA PRA Category 1 Credit(s)™AMA PRA Category 1 Credit(s)™
- 1.00 Hours of ParticipationHours of Participation credit.

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