Program Description: 

 

ISTH Academy Webinar: Human Platelet Generation in Vitro
 

Koji Eto "iPS cell-derived Megakaryocytes"

To supply transfusion products of 200-300 billion platelets derived from human induced pluripotent stem (iPS) cells ex vivo, the manipulation of megakaryopoiesis and platelet shedding must be considered. Dr. Eto will introduce an overview of an in vitro differentiation method for megakaryocytes and discuss how to increase the cell number from our cryopreserved self-renewing megakaryocyte cell line, immortalized megakaryocyte cell line (imMKCL), which was established from human iPS cells.

 

Peter Newman "'Designer' Platelets"

Dr. Newman will discuss the use of CRISPR/Cas9 technology to modify the genome of human induced pluripotent stem (iPS) cells prior to their differentiation into megakaryocytes and platelets so that patient-matched Designer Platelets can be generated. Platelets and their hematopoietic progenitor cells expressing specific, low-frequency platelet alloantigens may be of immediate use for research and for clinical diagnostic typing, and for future therapeutic use once the technology for producing large numbers of in vitro-derived platelets matures.

 

Jonathan Thon, PhD, CEO, Chief Scientific Officer, Co-Founder 

Jonathan is currently an Assistant Professor at Harvard Medical School. Jonathan received his Ph.D. in Biochemistry and Molecular Biology from the University of British Columbia, Canada, where he worked closely with Canadian Blood Services for the improvement of the processing and storage of blood platelets. Jonathan co-developed PBG’s bio-mimetic microfluidic platform to generate human platelets. 

 
Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of The Medical College of Wisconsin and International Society on Thrombosis and Haemostasis. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
 
Designation of Credit Statement:
The Medical College of Wisconsin designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
More information and online registration:  http://academy.isth.org/ 
 

 


 
Target audience: 

Physicians, Fellows, trainees and experienced professionals looking for an update

 

Learning objectives: 

At the end of this Webinar, the participants will be able to:

  • The audience will become familiar with human diseases caused by naturally-occurring polymorphisms in the genes encoding human platelet membrane glycoproteins.
  • The audience will become familiar with CRISPR/Cas9 technology and its use in modifying the genes of cells in culture, including human iPS cells.
  • The audience will learn about the early phase of hematopoiesis and late phase of megakaryopoiesis from differentiated human iPS cells. Understanding on how blood generation efficiency and functionality depends upon heterogeneous characteristics of the iPS cells will be explored.
Faculty & credentials: 
Planning Committee:
Geoffrey Barnes, MD
Chris Ward, PhD
Stephen Watson, PhD

 

Speakers:
Stacy Croteau
Scott Kaatz
 
 
Moderator:
Suthesh Sivapalaratnam

All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:  

 

 

Name

Company

Role

Geoffrey Barnes, MDBMS/Pfizer, Blue Cross Blue Shield of MI, AralezResearch Grant, Consulting
Chris Ward, PhDAlexian, Bayer, Boehringer Ingelheim, Roche, Pfizer/BMS, Sanofi-aventis, CSL, Janssen, AmgenSpeaker, Advisory Board, Sponsored attendee, Speaker, Project Supervisor
Peter NewmanBloodWorks Northwest, University of Pennsylvannia, ATVB, Vanderbilt University

Scientific Advisory Board, External Reviewer, Editor, Speaker

 

Koji EtoMegakaryon Co., LtdFounder
Jonathan ThonPlatelet BioGenesis, Ionis PharmaceuticalsConsultant, Co-Founder, Research

 
In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships. These relationships were reviewed via the MCW conflict of interest resolution process and resolved

 

 

 

 

Contact

Name: 
Lacey Schmeidler, MA
Phone number: 
+1 (919) 929-3807
Email: 
[email protected]
Session date: 
02/07/2017 - 5:00pm to 6:00pm CST
Location: 
ISTH Webinar Library Once a Month
Carrboro, NC 27510
United States
See map: Google Maps
Add to calendar: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.

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