September 20, 2017 15:00 - 16:00 UTC

Speakers:

Steve Kitchen "Measurement of novel and extended half-life FVIII products"

Stefan Tiefenbacher "Measurement of the extended half-life FIX products "

Moderator: Annette Bowyer, Royal Hallamshire Hospital (UK)

Steve Kitchen "Measurement of novel and extended half-life factor VIII products"

This presentation will review chromogenic and one stage FVIII assay data with different kits and reagents for monitoring 3 different pegylated FVIII molecules, Fc Fusion FVIII and  a novel single chain recombinant FVIII to clarify the options available to laboratories.

Stefan Tiefenbacher "Measurement of the extended half-life factor IX products"

This presentation will review available one-stage and chromogenic FIX activity assay data for the three novel (Extended Half-Life) EHL rFIX molecules (Fc-fusion, glycol-pegylated and albumin fusion rFIX). and discuss challenges and available options for clinical laboratories when monitoring these products in patient samples.

Moderator: Annette Bowyer

Biographies

Steve Kitchen

Dr. Steve Kitchen is the lead scientist in the department of Coagulation at Sheffield Haemophilia and Thrombosis Centre, Sheffield Teaching Hospitals. The centre is designated an International Haemophilia Training Centre by World Federation of Haemophilia. In addition he serves as Scientific Director of the UK National External Quality Assessment  Scheme  for Blood Coagulation and Director of the World Federation of Hemophilia's International External Quality Assessment Schemes for Blood Coagulation.He also serves on numerous working groups and committees including the Steering Committee for Steering committee UK NEQAS Blood Coagulation and as Associate Editor of the Journal of Thrombosis and Haemostasis. He has previously served on the ISTH Education Committee and as an Associate Editor for Seminars in Haemostasis and Thrombosis.

Stefan Tiefenbacher

Dr. Stefan Tiefenbacher is the Vice President of Laboratory Corporation of America® Holdings and the Technical Director of Coagulation, Colorado Coagulation, A LabCorp Speciality Testing Group.

Dr Tiefenbacher earned his PhD in Neuroscience and Behavior at the University of Massachusetts in 2002.  He completed fellowships in Psychiatry and Pharmacology at Harvard Medical School and the University of Colorado Health Sciences Center.  Dr Tiefenbacher joined the Colorado Coagulation team as Scientific Director in 2005, where he directs and oversees the scientific and technical aspects of clinical and clinical trial testing, as well as assay development and validation.  Dr Tiefenbacher has more than 10 years of experience in assay validation in both the bioanalytical, as well as good clinical practice (GCP) setting.  He is an active contributor at the Clinical Laboratory Standards Institute (CLSI) and a member of the International Society on Thrombosis and Haemostasis and the World Federation of Hemophilia.

Annette Bowyer

Annette Bowyer is the lead Biomedical Scientist for the Haemophilia Assays section in the Department of Coagulation at Sheffield Haemophilia and Thrombosis Centre.  The Centre is a designated International Haemophilia Training Centre by the World Federation of Haemophilia.  Dr Bowyer was awarded her PhD in Cardiovascular Science from the University of Sheffield with a thesis focusing on the laboratory diagnosis of mild Haemophilia A.  She has more than 15 years experience in the diagnosis and monitoring of bleeding disorders with a current interest in laboratory issues surrounding extended half-life treatment products for Haemophilia.  Dr Bowyer is a fellow of the Institute of Biomedical Science and member of the International Society on Thrombosis and Haemostasis and the World Federation of Haemophilia.