Keith Neeves "Blood flow regulation of coagulation"
Keith Neeves obtained his B.S. in chemical engineering at the University of Colorado, Boulder and a Ph.D. in chemical and biomolecular engineering at Cornell University. He was an NIH NRSA postdoctoral fellow in the Institute for Medicine and Engineering at the University of Pennsylvania. His lab at the Colorado School of Mines investigates biophysical mechanisms that regulate hemostasis and thrombosis. His research has been recognized with NSF CAREER, Colorado Bioscience Association Educator of the Year, and BMES Young Innovator awards and is supported by grants from National Institutes of Health, Department of Energy, National Science Foundation, and American Heart Association.
Pierre Mangin "Platelet adhesion under flow to vascular wall extracellular matrix proteins beyond collagen"
Pierre Mangin obtained his PhD studies in Molecular and Cellular Biology at the University of Strasbourg, France in 2003. His phD studies were focused on the signaling mechanism of the platelet receptors GPIb-IX-V and GPVI. He completed a post-doctoral internship at the Australian Centre for Blood diseases in the group of Shaun Jackson, Melbourne (2003-2006). There, he pursued his work on the role of adhesive platelet receptors in hemostasis and arterial thrombosis. He is currently Research Director (Directeur de Recherche Inserm) of the Inserm U1255 research team and scientific director of the Etablissement-Français du Sang-Grand-Est. His research remains focused on understanding the role of platelet adhesion receptors, such as the GPIb-IX complex, b1 integrins and GPVI, in hemostatic and non-hemostatic functions of platelets. Since 2018, he has been the Chair of the Scientific and Standardization Committee’s subcommittee on Biorheology of the International Society of Thrombosis and Haemostasis.
Moderator: David Bark
Supported by an unrestricted educational grant from: Instrumentation Laboratory
- 1.00 AMA PRA Category 1 Credit(s)™AMA PRA Category 1 Credit(s)™
- 1.00 Hours of ParticipationHours of Participation credit.
The ISTH webinar series will provide high quality and state of the art education to practitioners around the world. Throughout the course of the year, the series will provide both clinical and basic science education in the areas of Thrombosis and Anticoagulation; Platelets and Vascular Biology; Coagulation and Bleeding Disorders.
The presentation will cover the interaction of blood platelets with several extracellular matrix proteins found in different layers of the vessel wall. There will be a special focus on two adhesive proteins, namely laminins and fibronectin.
Researchers and clinicians with an interest how blood flow regulates hemostasis and thrombosis in vivo and ex vivo. Researchers, clinicians and students having interest in the adhesive functions of blood platelets.
- Participants will learn to describe how blood flow can both promote and inhibit coagulation
- Participants will learn to describe how an evolving thrombus protects coagulation products from dilution by flow
- Participants will learn to understand how certain geometries like those found in venous valves and extracorporeal devices exacerbate thrombosis
- Participants will gain an understanding of the current knowledge of the interaction between adhesive proteins of the vessel wall and blood platelets under flow conditions.
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following persons:
|Geoffrey Barnes, MD, MSc||BMS/Pfizer, NHLBI, Blue Cross Blue Shield of Michigan, Portola Janssen||Research Investigator, Consultant|
|Meera Chitlur, MD||Bayer, Genentech, Novo nardisk, Baxter||Advisory Board, Consultant, Speaker|