Program Description: 

The Medical College of Wisconsin (MCW) has a mission to be the national leader in providing high quality healthcare. One of the ways that we are doing this is to provide high quality continuing medical education (CME) to our faculty; this includes presentation from national leaders in the field of Nephrology. Our education al topics focus on outcomes research in chronic kidney disease and end-stage renal disease, delivery of care in dialysis units and chronic kidney disease clinics, emerging data on new treatments compared to current standard of care, continuing review of kidney biopsy pathology, and basic science research that may become future therapeutics.

Target audience: 
  • Physicians
  • Physicians Assistants
  • Nurse/Nurse Practitioners
  • Medical Students
Learning objectives: 

At the end of this session, I will be able to:

  1. Explore the increase in peripheral vascular resistance (PVR) in chronic hypertension is thought to be a secondary response that occurs as a consequence of auto regulation.  But a failure to decrease PVR in response to salt loading causes salt sensitivity and salt-induced hypertension.
  2. Examine why primary impairment of vasodilation caused by smooth muscle expression of dominant negative PPAR gamma-P467L mutation, elevates peripheral vascular resistance and predisposes to salt sensitive hypertension.
  3. Examine why individuals with decreased PPAR gamma activity, such as patients with type 2 diabetes and metabolic syndrome, often develop salt sensitive hypertension and may be proper candidates for dietary sodium restriction.
Faculty & credentials: 
Planning Team Members:
Dawn Wolfgram, MD
Kevin Regner, MD



Curt D. Sigmund, PhD
James J Smith & Catherine Welsch Smith Professor of Physiology
Chair, Department of Physiology
Associate Director, Cardiovascular Research Center

All persons in control of content have NO relevant financial relationships to disclose with the exception of the following person(s):

In accordance with the ACCME®  Standards for Commercial Support Number 6, all in control of content disclosed any relevant financial relationships.  These relationships were reviewed via the MCW conflict of interest resolution process and resolved.


Carriann Horstead
Phone number: 
+1 (414) 955-0300
Session date: 
08/13/2019 - 3:30pm to 4:30pm CDT
Hub for Collaborative Medicine
8701 Watertown Plank
Hub Room A7520/7628
Milwaukee, WI 53226
United States
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.

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