Weekly grand rounds as a forum for clinical and basic research updates in neurology with respect to diagnosis and management of neurological disorders and advances in neuroscience. General areas of focus will include among others the following: neuromuscular, epilepsy, sleep, movement disorders, stroke and vascular disorders, neurodegenertive, dementia and memory disorders, headaches and cranial neuralgias, autonomic disorders, and general neurologic conditions.
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NIRS cerebral oximetry works as a noninvasive measurement that allows continuous measurement of cerebral oxygen availability. This monitor serves as a surrogate to invasive measures of venous pO2, often obtained from the jugular vein to estimate cerebral oxygen levels.
Preliminary data shows varied regional cerebral oxygen saturation and/or cytochrome oxidase redox state during interictal period and seizure activity depending on the seizure type.
The increased blood flow clearly coincided with epileptiform activity and continued to increase as the epileptiform activity built up.
Regional cerebral oxygen saturation increased in the epileptogenic focus, perhaps due to loss of cerebrovascular autoregulation.
The gap in existing technology is to simultaneously monitor cellular cytochrome c oxygenation, as a measure of mitochondrial function and oximetry for blood oxygenation. In order to move forward with an understanding of neuronal mitochondrial energy metabolism during seizures, we have developed a NIRS probe capable of measuring both regional cellular REDOX state of cytochrome c oxidase (CCO) in the neurons, and simultaneously measuring oxyhemoglobin-based regional cerebral oxygen saturation in real time.
Presenter: Harry Whelan, MD
Activity Director: Derrick Shumate, DO
Ann Helms, MD
Chad Carlson, MD
David Sabsevitz, PhD
All persons in control of content have NO relevant financial relationships to disclose.
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