Late effects in pediatric patients following hematopoietic cell transplantation (HCT)

Minneapolis , MN US
October 9, 2014

Advances in transplantation techniques and supportive care practices have led to steadily improving HCT survival rates for pediatric recipients. As HCT recipients survive long-term, the risk for developing late complications based on their pre-, peri-, and post-transplant exposures and individual risk factors increases.  Research has shown that after HCT, 93% of pediatric recipients have at least 1 adverse effect after 7 years of follow-up.[1] This high burden underscores the need for monitoring of conditions with significant morbidity to promote early detection and treatment.  Thus it is critically important that there are guidelines and training on the follow-up care of these survivors at risk for post-HCT complications.

Long-term, HCT recipients may no longer be under the care of their transplant team, returning to community health-care providers for their primary care. The risks and range of complications associated with HCT continues to evolve as new practices are continuously introduced. Keeping up with the latest care recommendations can challenge providers with limited exposure with patients after HCT to provide optimal care when these patients are seen in their practices. Their follow-up care may necessitate a number of disciplines being involved, dependent on the availability of providers and specialized care required.

Results from 1,110 general internists who expressed willingness to care for childhood cancer survivors revealed that only 37% and 27% reported being “somewhat comfortable” or “comfortable” caring for survivors of Hodgkin lymphoma and acute lymphoblastic leukemia, respectively.  Only 12% reported general familiarity with surveillance guidelines for childhood cancer survivors and 72% had never received a patient treatment summary.

A survey with 351 practicing internal medicine and family practice physicians was done by Simi et al. to identify barriers to providing late effects screening and useful tools for caring for pediatric survivors in their practice. Primary care providers were found to have: low level of awareness of late effects of cancer-directed therapy, inadequate training to recognize late effects, infrequent utilization of guidelines and the absence of cancer treatment summaries and survivorship care plans for patients (84-86% never received information).

To address follow-up care needs, several groups have developed screening and long-term follow up recommends for pediatric patients, including the Children’s Oncology Group.[2] These guidelines are risk-based and exposure- related.  The guidelines include a patient-specific identification tool to define and track individual treatment exposures to document their course of treatments and follow-up care.

ACCME Accreditation Statement:
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the Medical College of Wisconsin and National Marrow Donor Program. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.
 
AMA Credit Designation Statement:
The Medical College of Wisconsin designates this Enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 
Hours of Participation for Allied Health Care Professionals
The Medical College of Wisconsin designates this activity for up to 1.0 hours of participation for continuing education for allied health professionals.

Target Audience

This activity is intended for pediatric hematologist/oncologists and specialists who treat pediatric hematopoietic cell transplant recipients for malignant and non-malignant diseases.

Learning Objectives

At the conclusion of this activity, I will be able to

1. Identify the most common late effects experienced by pediatric HCT recipients that require ongoing follow up and care.

2. Use appropriate screening, testing and vaccination schedules from recommended guidelines according to each patient’s exposures and risk factors.

3. Utilize care planning tools as part of a patient’s multidisciplinary team of care providers to identify, document and communicate needs for follow-up care.

Additional information

CME Coordinator Contact Information

Name: 
Ellyce Hayes
Phone Number: 
+1 (612) 460-4231
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.
Course opens: 
10/01/2014
Course expires: 
12/31/2014
Event starts: 
10/09/2014 - 4:00pm
Event ends: 
10/09/2014 - 5:00pm
Cost:
$0.00
Live - Webinar
3001 Broadway Street NE
Suite 100
Minneapolis , MN 55413
United States
Planning Committee:
Mary Horowitz, MD
Navneet Majhail, MD, MS
Angela Smith, MD, MS
Kathy Welte
Melinda Baxter, RN, MSN
Jackie Foster, RN
Darlene Haven, BS
Ellyce Hayes, RD
 
 
Presenters:
Navneet Majhail, MD, MS
Angela Smith, MD, MS
 
All persons in control of content have NO relevant financial relationships to disclose with the exception of the following:

Available Credit

  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.

Accreditation Period

Course opens: 
10/01/2014
Course expires: 
12/31/2014

Price

Cost:
$0.00
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