Program Description: 

Though the root causes of glaucoma with damage and loss to retinal ganglion cells (RGCs) are numerous and diverse, emerging evidence indicates that subtypes of glaucoma and other neurodegenerative diseases may converge on mitochondrial dysfunction, highlighting a potential target site for treatment regardless of glaucoma subtype. We have used zebrafish to study glaucomatous phenotypes, and to develop novel tools for assessing mitochondrial damage and dysfunction. In this study, we will disrupt zebrafish opa1 whose mutations cause autosomal dominant optic atrophy (ADOA) via disruption of normal mitochondrial dynamics. Subsequently, we will assess therapeutic potential to restore normal mitochondrial dynamics in zebrafish RGCs using pharmacological approaches. 


Educational series covering all aspects clinical eye care in an academic setting. 

Key Words: 

  • Ophthalmology
  • Optometry
  • Clinical eye care
  • Diversity


Target audience: 
  • Ophthalmologists
  • Optometrists
  • Residents/Fellows
  • Medical Students
  • Community Physicians
Learning objectives: 

Participants who engage in this educational intervention will be able to:

  • Explore the advantages and disadvantages of using animal models to study optic nerve health.

  • Establish zebrafish optic neuropathy mutant models and characterize their phenotypes.

  • Test pharmacological candidates for therapeutic intervention to treat optic neuropathy.



Faculty & credentials: 

In accordance with the ACCME® Standards for Integrity and Independence in Accredited Continuing Education, Standard 3, all in control of content must disclose any relevant financial relationships. The following in control of content had no relevant financial relationships to disclose.


Ross F. Collery, PhD
Assistant Professor
Ophthalmology and Visual Sciences, Research 








Mary Schafer
Phone number: 
+1 (414) 955-7840

ACCME Accreditation Statement:

The Medical College of Wisconsin is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation Statement:

The Medical College of Wisconsin designates this for a maximum of 1.00 AMA PRA Category 1 Credit(s)™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Hours of Participation for Allied Health Care Professionals:

The Medical College of Wisconsin designates this activity for up to 1.00 hours of participation for continuing education for allied health professionals. 


Session date: 
03/02/2022 - 7:00am to 8:00am CST
The Eye Institute
925 N 87th Street
Milwaukee, WI 53226
United States
  • 1.00 AMA PRA Category 1 Credit(s)™
    AMA PRA Category 1 Credit(s)™
  • 1.00 Hours of Participation
    Hours of Participation credit.

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