Session 4: Epigenomics
Dr. Lomberk is an Associate Professor in the Department of Surgery and the Department of Pharmacology and Toxicology at MCW. She also serves as the Chief of the Division of Research and Director of Basic Science Research for the Department of Surgery. Prior, she spent 10 years at the Mayo Clinic as Assistant and then Associate Professor of Medicine in the Division of Gastroenterology and Hepatology. Her research career has been focused on epigenomic mechanisms of disease pathobiology and the use of epigenomic-based pharmacology to serve as a robust tool for improving the future treatment of cancer.
- In this course, students will discuss epigenetic events, the tools for the design and execution of research in this discipline, how to generate and analyze epigenomic data, and the application of Epigenomics to diagnostics, prognostics, and treatments.
-Understand the basic principles of epigenomics and their role in precision medicine: Participants should be able to distinguish the key concepts of epigenomics, including DNA methylation, histone modification, chromatin remodeling, and non-coding RNA regulation, and discuss how they contribute to gene expression and cellular function. Participants should be able to articulate the role of epigenetic modifications in various diseases.
-Identify potential clinical applications of epigenomics in precision medicine: Learners should be able to identify potential clinical applications of epigenomics in precision medicine, including the development of epigenetic biomarkers for disease diagnosis, prediction of response to therapy based on epigenetic signatures, and development of epigenetic therapies. They should also be able to recognize the challenges and opportunities associated with implementing epigenetic interventions in clinical practice, and the need for interdisciplinary collaboration and continued education.
- Create a framework for designing epigenomic studies in precision medicine: Participants should apply critical thinking skills to design and plan epigenomic studies that address specific research questions related to precision medicine. They should also be able to implement these studies using current state-of-the-art technologies and techniques used for epigenomic analysis, including RNA-seq, ChIP-seq, and ATAC-seq.